Striped, Ellipsoidal Particles by Controlled Assembly of Diblock Copolymers

In a first step, elongated particles with an axially stacked lamellae structure are selectively prepared by utilizing functional surfactants to control the phase separation of symmetric polystyrene-b-poly(2-vinylpyridine)(PS-b-P2VP) in dispersed droplets. In a second step, the dynamic shape change is realized by cross-linking the P2VP domains, thereby connecting glassy PS discs with pH-sensitive hydrogel actuators.

Polymer Nanoparticles for Drug Delivery Applications


Nanotechnology offers a range of unique opportunities in the fields of diagnostic and therapeutic medical applications with significant advances in the design and application of tailored nanoparticle-based drug delivery platforms, paving the way for further progress in cellular biology and clinical and imaging sciences. A guiding principle in this rapidly growing biomedical area is the ability of nanoparticles to mimic the high affinity, multivalent interactions that exist in cellular systems in order to produce highly efficient, diagnostic and therapeutic synthetic systems.