Pushing the Limits for Thiol-Ene and CuAAC Reactions: Synthesis of a 6th Generation Dendrimer in a Single Day.

graphical abstract
Antoni, P.; Robb, M.J.; Campos, L.; Montanez, M.; Hult, A.; Malmstrom, E.; Malkoch, M.; Hawker, C.J.;
Macromolecules,
2010
43, 6625-6631.

Dendrimer synthesis should not be tedious and time-consuming. By utilizing an AB2−CD2 approach and having orthogonal, “clickable” groups on each monomer, the time for dendrimer assembly can be drastically reduced. This was shown by preparation of a sixth generation dendrimer from starting monomer units in a single day.