One-Pot Reaction Cascades Using Star Polymers with Core-Confined Catalysts

star polymers
Helms, B.; Guillaudeu, S. J.; Xie, Y.; McMurdo, M.; Hawker, C. J. and Frechet, J. M. J.;
Angew. Chem., Int. Ed.
44, 6384-6387.

My stars! Star polymers that contain otherwise incompatible acid or base catalysts, such as para-toluenesulfonic acid or 4-(dialkylamino)pyridines moieties, at their sterically restricted cores (see scheme) are readily prepared. Homogeneous catalysis using these star polymers can perform reaction cascades in the same pot and is demonstrated with an acid-catalyzed deprotection and the nucleophilic amine-catalyzed Baylis–Hillman reaction.