Multifunctional Trackable Dendritic Scaffolds and Delivery Agents

Amir, R.J.; Albertazzi, L.; Willis, J.; Khan, A.; Kang, T.; Hawker, C.J.
Angew. Chem., Int. Ed.
2011
50, 3425-3429

Dual action: Trackable multifunctional dendritic scaffolds with high internal loading capacity were synthesized based on a PEG core. Orthogonal functionalization of chain-end and internal groups allowed the dendrimers to be both labeled and loaded with releasable dyes for simultaneous monitoring of the dendritic carrier and release of the dye payload inside living cells (see picture).