A General Approach to Sequence-Controlled Polymers Using Macrocyclic ROMP

Gutekunst, W. R., Hawker, C. J.
J. Am. Chem. Soc.
137 (25), pp 8038–8041

A new and general strategy for the synthesis of sequence-defined polymers is described that employs relay metathesis to promote the ring opening polymerization of unstrained macrocyclic structures. Central to this approach is the development of a small molecule “polymerization trigger” which when included in a programmed macrocyclic structure allows for the controlled, directional synthesis of sequence controlled polymers.