Jos Paulusse studied Chemical Engineering at the Eindhoven University of Technology in the Netherlands. This study was completed in 2002 with a graduation project at the Laboratory of Homogenous Catalysis and Coordination Chemistry under guidance of prof. Dieter Vogt. He started his Ph.D. research at the Laboratory of Macromolecular and Organic Chemistry under guidance of prof. Rint Sijbesma and prof. Bert Meijer. In September 2006, he successfully defended his thesis entitled Reversible Mechanochemistry of Coordination Polymers and Networks. After a short post-doctoral stay at the same group he moved to Santa Barbara, to start his post-doctoral research in the group of Prof. Craig Hawker.
Jos research entails the development of polymer nanoparticles for disease targeting, drug delivery, and imaging. As part of the PEN-project, he is investigating the synthesis of biodegradable polymers via radical ring-opening polymerization of cyclic acrylates. Jos is also investigating the preparation of single polymer nanoparticles. These nanoparticles are prepared by intramolecular collapse of isocyanate-grafted PMMA polymers with diamine crosslinkers. Being a supramolecular chemist, Jos is investigating the use of supramolecular crosslinkers such as the quadruple hydrogen bonding unit. These nanoparticles may be used as a scaffold for targeting and imaging agents and may help understand and treat diseases.